2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P3924
    Agouti-Related Protein (54-82) (human) 209460-63-9 98%
    Agouti-Related Protein (54-82) (human) (AGRP (54-82) (human)) is an amino-terminal 54-82 fragment of agouti-related protein (AGRP).
    Agouti-Related Protein (54-82) (human)
  • HY-P3925
    [His11]Substance P 98%
    [His11]Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.
    [His11]Substance P
  • HY-P3927
    [MePhe8,Sar9] Substance P 77128-76-8 98%
    [MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS.
    [MePhe8,Sar9] Substance P
  • HY-P3930
    PKI (5-24),amide 100891-36-9 98%
    PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a Ki of 2.3 nM.
    PKI (5-24),amide
  • HY-P3932
    [Sar4] Substance P (4-11) 98%
    [Sar4] Substance P (4-11) is an analog of Substance P (4-11). Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist.
    [Sar4] Substance P (4-11)
  • HY-P3933
    [Tyr8,Nle11] Substance P 71890-48-7 98%
    [Tyr8,Nle11] Substance P is a Substance P (HY-P0201) analog. Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation.
    [Tyr8,Nle11] Substance P
  • HY-P3943
    Calmodulin Dependent Protein Kinase Substrate Analog 123067-01-6 98%
    Calmodulin Dependent Protein Kinase Substrate Analog is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases.
    Calmodulin Dependent Protein Kinase Substrate Analog
  • HY-P3944
    Calmodulin Dependent Protein Kinase Substrate 82801-68-1 98%
    Calmodulin Dependent Protein Kinase Substrate is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases.
    Calmodulin Dependent Protein Kinase Substrate
  • HY-P3945
    Prolactin-Releasing Peptide (12-31), bovine 209466-90-0 98%
    Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP). PrRP is RF-amide peptides expressed in brain areas involved in pain modulation. Prolactin-Releasing Peptide (12-31), bovine can be used for the research of nervous system disease.
    Prolactin-Releasing Peptide (12-31), bovine
  • HY-P3958
    BIM-23027 78981-49-4 99.76%
    BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism.
    BIM-23027
  • HY-P3967
    Thymopoietin i/ii (29-41) (bovine) 56795-64-3 98%
    Thymopoietin i/ii (29-41) (bovine) is a peptide corresponding to positions 29-41 of bovine thymopoietin II. Thymopoietin i/ii (29-41) (bovine) is a neuromuscular blocker.
    Thymopoietin i/ii (29-41) (bovine)
  • HY-P3969
    Prepro-TRH-(160-169) 122018-91-1 98%
    Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.
    Prepro-TRH-(160-169)
  • HY-P3978
    ACTH (4-9) 56236-83-0 98%
    ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.
    ACTH (4-9)
  • HY-P3981
    Defensin NP-3A 134090-73-6 98%
    Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity.
    Defensin NP-3A
  • HY-P3993
    (Gly14)-Humanin (human) 330936-70-4 98%
    (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
    (Gly14)-Humanin (human)
  • HY-P4009
    [Lys8] Vasopressin Desglycinamide 32215-99-9 98%
    [Lys8] Vasopressin Desglycinamide is a vasopressin analog, used for the maintenance of active and passive avoidance behavior. [Lys8] Vasopressin Desglycinamide facilitates memory consolidation processes.
    [Lys8] Vasopressin Desglycinamide
  • HY-P4011
    [1,6-Aminosuberic acid]-arginine-Vasotocin 35375-13-4 98%
    [1,6-Aminosuberic acid]-arginine-Vasotocin is a synthetic peptide analogue to neurohypophyseaI hormones. [1,6-Aminosuberic acid]-arginine-Vasotocin has excitatory effect on the periodically oxcillating neuron (PON) of A. fulica.
    [1,6-Aminosuberic acid]-arginine-Vasotocin
  • HY-P4015
    VIP (1-12), human, porcine, rat, ovine 120928-03-2 98%
    VIP (1-12), human, porcine, rat, ovine is a vasoactive intestinal peptide (VIP) fragment. VIP (1-12), human, porcine, rat, ovine is a ligand for the CD4 (T4)/human immunodeficiency virus receptor.
    VIP (1-12), human, porcine, rat, ovine
  • HY-P4040
    Ac-D-DGla-LI-Cha-C 208940-40-3 98%
    Ac-D-DGla-LI-Cha-C is a potent HCV protease inhibitor peptide. Ac-D-DGla-LI-Cha-C can be used for the research of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases.
    Ac-D-DGla-LI-Cha-C
  • HY-P4106
    Tat-GluR23Y, scrambled 1404188-94-8 98%
    Tat-GluR23Y, scrambled is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD).
    Tat-GluR23Y, scrambled
Cat. No. Product Name / Synonyms Application Reactivity